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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Ketoconazole
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Culture in the presence of all-trans-retinoic acid decreased the half-life twofold and resulted in an increased sensitivity of retinoic acid degredation to ketoconazole.”
Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation.“In both endothelial cells and hepatocytes all-trans-retinoic acid metabolism was inhibitable by the cytochrome P-450 inhibitors liarozole (10 microM) and ketoconazole (10 microM), albeit to different extents and with different specificities.”
“It is concluded that the in vivo effect of CYP inhibitors (DEDTC and KC ) on the elimination rate of ATRA is qualitatively different from that expected from in vitro studies.”
“Metabolism of [3H]-retinoic acid by TA3 Ha cells was inhibited by the cytochrome P-450 inhibitors ketoconazole , clotrimazole, and liarozole.”
“Administration of ketoconazole or R 75 251 (40 mg/kg, -2 hr) to rats also enhanced endogenous plasma concentrations of RA.”
“injected RA from plasma: the half-life of RA increased from 27 min in control-treated animals to 43 min and 76 min after dosing with ketoconazole and R 75 251, respectively.”
Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats.“ Ketoconazole and miconazole, imidazole antifungal agents and inhibitors of some fungal and mammalian P450-dependent enzymes, inhibit in vitro RA metabolism by rat epidermal microsomes.”
“They also suggest that ketoconazole is capable of prolonging the biological half-life of RA and of improving the tissue levels of this compound.”
“An inhibitor of oxidative metabolism, ketoconazole , decreased the rate of retinoic acid metabolism and decreased the concentration of retinoic acid required to produce a half-maximum response.”
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