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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ketoconazole
supplement:
Carboxyamidotriazole
Research Papers that Mention the Interaction
“In most patients administration of ketoconazole produced an increase in CAI AUC and Cmax with a decrease in CAI clearance.”
“In vitro, ketoconazole has been demonstrated to inhibit CYP3A4-mediated metabolism of CAI.”
A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer“These studies suggest that elevated levels of CAI may result from P450 3A4 inhibition by ketoconazole if these two drugs are coadministered.”
Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo
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