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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ketoconazole
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Ketoconazole inhibits in vitro (IC50:2.6 X 10(-5) M) the formation of 5-HETE and LTB4 by isolated, carrageenin-elicited rat peritoneal PMN leukocytes, challenged with the Ca2+ -ionophore A23187 in the presence of [14C]-arachidonic acid ([14C]-AA).”
Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo.“Further, we identified that ketoconazole suppressed CA 1β-hydroxylation and that the CYP3A subfamily was the primary group of enzymes responsible for CA-1β-ol formation.”
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