Possible Interaction: Ketoconazole and Adrenocorticotropic Hormone

“ConclusionMTP and/or KTZ may reduce ACTH and cortisol production.”

“ ACTH levels during ketoconazole treatment are controversial.”

“Plasma ACTH levels were stimulated 2–50 fold by ketoconazole.”

“Addition of ketoconazole to the culture medium decreased ACTH secretion showing that ketoconazole had a direct effect on the tumour cells.”

“These data show that ketoconazole induce marked changes on corticotrope morphology and ACTH secretion in pituitary cells obtained from patients with Nelson's syndrome.”

“The enhanced response of ACTH to oCRH after the administration of ketoconazole argues against an inhibitory effect of this agent at the pituitary level and might best be explained by reduced negative Cortisol feedback.”

“ Ketoconazole , an oral antifungal, when given in conventional doses, transiently blocks testosterone synthesis and adrenal response to corticotropin.”

“Although ketoconazole significantly increased the concentration of ACTH in trunk blood, there were no significant effects on plasma cortisol, corticosterone or testosterone.”

“In addition, basal and CRF-stimulated mRNA coding for the ACTH precursor were reduced after preincubation with KC.”

“ KC inhibits CRF-stimulated ACTH release from rat anterior pituitary fragments in a dose-dependent fashion between 1.5 and 100 microM. The effect of CRF as a releaser of ACTH was fully restored after KC was removed from the medium.”

“ KC inhibits the corticotropin releasing hormone (CRH) stimulated ACTH release from rat anterior pituitary fragments in a dose dependent fashion between 1.5 and 100 microM. The effect of CRH to release ACTH was fully restored after KC was removed from the medium.”

“Similar effects were observed in primary cultures of rat anterior pituitary cells: KC decreased dose dependently the basal and CRH stimulated ACTH release.”