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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Intrathecal pretreatment with yohimbine (10 μg) or methysergide (15 μg) completely reversed the anti-hypersensitivity effects of systemic ketamine.”
Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats“Further, pretreatment with an intrathecal serotonin antagonist, methysergide, and an intrathecal alpha 2 adrenergic antagonist, yohimbine , abolished the antinociceptive effects of intraperitoneal ketamine in the TF and the MPP tests.”
“Concurrent exposure to ketamine hydrochloride, xylazine, and yohimbine , an alpha 2 adrenergic receptor antagonist, resulted in corneal lesions in only 6% of rat pups so exposed.”
“ Yohimbine , an alpha-2 adrenergic antagonist has been shown to reverse xylazine induced depression and partially antagonize ketamine in other species.”
“ Yohimbine hydrochloride has been used experimentally to reverse the anesthetic effects of ketamine and xylazine in dogs, cats, cattle and mule deer, but there are no reports of its use in nonhuman primates.”
“ Yohimbine hydrochloride (YH) effectively reversed the immobilizing effects of ketamine hydrochloride (KH) combined with xylazine hydrochloride (XH) in 48 wild polar bears (Ursus maritimus) handled in the summer.”
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