Possible Interaction: Ketamine and Vitamin C

“These findings contribute to understand the cellular targets implicated in its antidepressant/anxiolytic behavioral responses and support the notion that ascorbic acid may share with ketamine the ability to increase synaptic function.”

“Our results revealed that a single administration of subeffective doses of ascorbic acid and ketamine completely reversed the depressive-like behavior induced by CUS, however, this effect was not accompanied by changes in the phosphorylation of p70S6K and immunocontent of GLUA1 or PSD95 in the hippocampus.”

“These findings point to a synergistic antidepressant-like effect of ascorbic acid and ketamine , paving the way for additional studies on the combined use of these compounds for the management of major depressive disorder (MDD).”

“Our data indicates an effect for AA in preventing alterations induced by Ket in an animal model of SZ, suggesting that it may be an adjuvant approach for the development of new therapeutic strategies within this psychiatric disorder.”

“The observed decreased in serum calcium and phosphorous following ketamine injection was prevented by pretreatment with vitamin C. These results suggest that vitamin C at higher doses could potentiate ketamine anesthesia in rabbits.”

“There was also significant (p < 0.05) decrease in the heart rates in the animals treated with vitamin C and ketamine combinations.”

“Interference studies involved administering AA and subanaesthetic doses of ketamine i.p.”