“As blockade of NMDARs is one of the main mechanisms responsible for the action of ketamine on central nervous system, DMG might modulate the behavioral responses to ketamine.”
“In addition, DMG alone exhibited antidepressant-like effects in the forced swim test and produced additive effects when combined with ketamine.”
“These results reveal that DMG could antagonize ketamine 's psychotomimetic effects, yet produce additive antidepressant-like effects with ketamine, suggesting that DMG might have antipsychotic potential and be suitable as an add-on therapy to ketamine for patients with treatment-resistant depression.”