supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“These results indicate that IV thiamylal and ketamine both suppress the increases of myoglobin, CK, and potassium , and that in cases when succinylcholine is used, both drugs can help to avoid myoglobinemia and limit the increases of CK and potassium. (”
The Effect of Ketamine or Thiamylal on Succinylcholine-Induced Myoglobinemia Under Halothane Anesthesia in Adults“The … ketamine was fully antagonized by the potassium channel blockers cesium chloride and barium chloride (8 [26]% and 39 [58%] increase, respectively, P < … was facilitated by the potassium leak channel opener urethane (–93 [8]%, P = 0.002 compared to ketamine control) and low potassium artificial cerebrospinal fluid (–… ketamine control).”
Ketamine Action in the In Vitro Cortical Slice Is Mitigated by Potassium Channel Blockade“CONCLUSION Ke amine pr oduces significant inhibition of pot assium cu rrents in the central neurons, which may least partly explain at the action of ketamine.”
“The effect of high potassium could be prevented by Ketamine , but not by APV.”
“Conclusions Although both ketamine and halothane inhibit potassium currents through the Kv2.1 channel, their mechanisms of action at this potential target may be different.”
“ Ketamine blocked potassium- and thromboxane A2-stimulated 45Ca uptake in a dose-dependent manner, but had no effect on basal 45Ca uptake, the externally bound 45Ca content, or the volume of the 3H-sorbitol space.”
“ Ketamine produced dose-related relaxation of arteries preconstricted with potassium , a stable thromboxane A2 analogue, or endothelin.”
“These results indicate that ketamine can directly dilate cerebral arteries by acting as a calcium channel antagonist; ketamine inhibits 45Ca uptake through both potential-operated ( potassium ) and receptor-operated (thromboxane A2) channels in cerebrovascular smooth muscle.”
“Diazepam, propanidid and ketamine induced relaxation and antagonized histamine-, acetylcholine-and potassium chloride-induced contractures in the tracheal smooth muscle.”
“At 10 −3 M , ketamine acted to simultaneously depolarize the postsynaptic membrane and increase the effective membrane resistance by decreasing the membrane conductance to potassium.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback