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Last Updated: 3 years ago

Possible Interaction: Ketamine and Niacin

supplement:

Niacin

Research Papers that Mention the Interaction

Volatile anesthetics and ketamine are potent inhibitors of nicotinic nAch receptors with clinically relevant IC50 values (6).
Acta anaesthesiologica Scandinavica  •  2003  |  View Paper
Although numerous other receptors (e.g., GABA, nicotinic acetylcholine, opiate, voltage-operated channels) have been reported to interact with ketamine , their role in inducing dissociative anaesthesia is still under discussion.
Der Anaesthesist  •  1997  |  View Paper
Several anesthetic drugs are nicotinic antagonists at or below levels used for anesthesia, including ketamine and volatile anesthetics.
Anesthesia and analgesia  •  2005  |  View Paper
Nicotinamide and ketamine decreased brain swelling and DNA fragmentation in the cerebral cortex, striatum and hippocampus in rats perfused for 6 or 24 h. Ketamine may synergize the actions of nicotinamide and partially prevent brain damage from ischemia and reperfusion.
The combination of ketamine and nicotinamide decreased infarct volume to 83.8 +/- 35.2 mm(3).
Neuroscience Letters  •  2002  |  View Paper
These observations indicate that ketamine , at clinical concentrations, can inhibit nicotinic receptor-associated ionic channels and that the inhibition of Na influx via the receptor-associated ionic channels is responsible for the inhibition of carbachol-induced Ca influx and catecholamine secretion.
European journal of pharmacology  •  1986  |  View Paper
Ketamine (90 microM and over) depressed the nicotinic responses of the ganglia.
European journal of pharmacology  •  1984  |  View Paper
Both ketamine and phencyclidine specifically inhibited nicotinic agonist-induced secretion at concentrations which did not alter secretion induced by elevated K+ depolarization.
Life sciences  •  1984  |  View Paper
In concentrations greater than 10 −3 M , ketamine acted non-selectively to block reversibly the nicotinic , muscarinic and non-cholinergic ganglionic responses.
Neuropharmacology  •  1976  |  View Paper
Collectively, these experimental results demonstrate that ketamine inhibits the CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors and the membrane depolarization from the isolated perfused rat adrenal gland.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology  •  2008  |  View Paper