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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Serotonin and N-acetyl serotonin which augmented ketamine DOC, did not do so in the absence of the pineal gland, whereas melatonin potentiated the ketamine DOC in both the intact and pinealectomized chick.”
Effects of amine pretreatment on ketamine catatonia in pinealectomized or hypophysectomized animals.“RESULTS Ketamine administered during the resting phase produced 65- and 153-minute phase advances, respectively, in melatonin secretion and locomotor activity rhythms on the first day after anesthesia.”
Day or Night Administration of Ketamine and Pentobarbital Differentially Affect Circadian Rhythms of Pineal Melatonin Secretion and Locomotor Activity in Rats“ Melatonin pretreatment caused rapid onset of anesthesia after ketamine and thiopental sodium administration while the duration of action of these agents was prolonged.”
“This study suggests that melatonin modulate mechanisms involved in induction of thiopental sodium and ketamine anesthesia.”
“Our results indicated that halothane attenuated the release of melatonin and pentobarbital had no apparent effect, whereas ketamine potentiated the release of melatonin.”
“These findings suggest that melatonin levels may be affected in patients anaesthetized with halothane or ketamine , resulting in disturbed biological rhythms, especially the sleep-wake cycle following recovery.”
“ Melatonin was the most potent in augmenting the ketamine response of those indoleamines tested.”
“When chicks were pretreated with serotonin, N-acetylserotonin or melatonin , the ketamine response was augmented.”
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