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Last Updated: 2 years ago

Possible Interaction: Ketamine and Magnesium

supplement:

Magnesium

Research Papers that Mention the Interaction

The evidence in the paper discussed may indicate the synergistic interaction between magnesium and ketamine pharmacodynamic activity being of particular importance in mood disorders.
Magnesium research  •  2018  |  View Paper
There is overlap between the actions of ketamine with that of high doses of magnesium in animal models, finally leading to synaptic sprouting.
Journal of psychiatric research  •  2013  |  View Paper
The authors hypothesized that ketamine in neuropathic pain may provide pain relief and cognitive-emotional benefit versus placebo and that a combination with magnesium may have an additive effect for 5 weeks.
Anesthesiology  •  2020  |  View Paper
The authors hypothesized that ketamine in neuropathic pain may provide pain relief and cognitive-emotional benefit versus placebo and that a combination with magnesium may have an additive effect for 5 weeks.
The authors hypothesized that ketamine in neuropathic pain may provide pain relief and cognitive–emotional benefit versus placebo and that a combination with magnesium may have an additive effect for 5 weeks.
Anesthesiology  •  2020  |  View Paper
Combination of ketamine and magnesium in a normal magnesium level presents a superadditive effect in depression treatment.
Magnesium … ketamine have a common mechanism of action in the treatment of depression: an increase in GluN2B (NMDAR subunit) expression is related to the administration of … as inhibition of phosphorylation of eEF2 (eukaryotic elongation factor 2) in cell culture and increase of the expression of BDNF in the hippocampus.
The synergistic interaction between the pharmacodynamic activity of magnesium and ketamine may be of particular importance for patients with mood disorders.
Psychiatria Danubina  •  2019  |  View Paper
Furthermore, the association of ketamine with magnesium has been poorly studied.
Trials  •  2017  |  View Paper
Ketamine and magnesium as NMDA receptor antagonists interact synergistically to decrease body temperature in rats.
Journal of thermal biology  •  2018  |  View Paper
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone.
Ketamine , when administered before or after the magnesium , provided additive or antagonistic antinociceptive interactions, respectively.
Whether there will be an additive or antagonistic antinociceptive interaction between ketamine and magnesium depends on the order of drug administration.
Acta neurobiologiae experimentalis  •  2017  |  View Paper
Magnesium may potentiate the effect of ketamine in analgesia and anaesthesia, but may also interact in an opposing manner.
European review for medical and pharmacological sciences  •  2015  |  View Paper
It is possible that the synergy between ketamine and magnesium may have clinical relevance.
Physiology & Behavior  •  2014  |  View Paper
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