Possible Interaction: Ketamine and Magnesium

“The evidence in the paper discussed may indicate the synergistic interaction between magnesium and ketamine pharmacodynamic activity being of particular importance in mood disorders.”

“There is overlap between the actions of ketamine with that of high doses of magnesium in animal models, finally leading to synaptic sprouting.”

“The authors hypothesized that ketamine in neuropathic pain may provide pain relief and cognitive-emotional benefit versus placebo and that a combination with magnesium may have an additive effect for 5 weeks.”

“The authors hypothesized that ketamine in neuropathic pain may provide pain relief and cognitive-emotional benefit versus placebo and that a combination with magnesium may have an additive effect for 5 weeks.”

“The authors hypothesized that ketamine in neuropathic pain may provide pain relief and cognitive–emotional benefit versus placebo and that a combination with magnesium may have an additive effect for 5 weeks.”

“Combination of ketamine and magnesium in a normal magnesium level presents a superadditive effect in depression treatment.”

“ Magnesium … ketamine have a common mechanism of action in the treatment of depression: an increase in GluN2B (NMDAR subunit) expression is related to the administration of … as inhibition of phosphorylation of eEF2 (eukaryotic elongation factor 2) in cell culture and increase of the expression of BDNF in the hippocampus.”

“The synergistic interaction between the pharmacodynamic activity of magnesium and ketamine may be of particular importance for patients with mood disorders.”

“Furthermore, the association of ketamine with magnesium has been poorly studied.”

“ Ketamine and magnesium as NMDA receptor antagonists interact synergistically to decrease body temperature in rats.”

“Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone.”

“ Ketamine , when administered before or after the magnesium , provided additive or antagonistic antinociceptive interactions, respectively.”

“Whether there will be an additive or antagonistic antinociceptive interaction between ketamine and magnesium depends on the order of drug administration.”

“ Magnesium may potentiate the effect of ketamine in analgesia and anaesthesia, but may also interact in an opposing manner.”

“It is possible that the synergy between ketamine and magnesium may have clinical relevance.”