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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Further, the anti-tumor effect of ketamine was reversed by d-serine (NMDAR activator).”
Ketamine inhibits colorectal cancer cells malignant potential via blockage of NMDA receptor.“Additionally, both responders and non-responders showed decreased D-serine plasma levels in a biphasic manner after ketamine infusion, although plasma levels of L-serine were not altered.”
“Pretreatment with ketanserin (5HT2A/2C receptor antagonist), M100907 (selective 5-HT2A receptor antagonist), D-serine (co-agonist of the NMDA receptor glycine site), and haloperidol (D2 receptor antagonist) significantly decreased toluene’s and ketamine ’s actions.”
Preclinical characterization of toluene as a non-classical hallucinogen drug in rats: participation of 5-HT, dopamine and glutamate systems“This effect of d-serine was inhibited by a variety of NMDA receptor antagonists ( ketamine , MK 801 and ifenprodil), suggesting that NMDA receptors are involved in the effects of d-serine on the neurogenic relaxation of corporal tissue strips.”
“Clinical studies have also shown that D-serine may be a biomarker for antidepressant response to ketamine.”
D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?
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