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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ketamine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In parallel, levels of intracellular calcium concentration- and time-dependently decreased after ketamine administration.”
Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function“Moreover, midazolam or ketamine pretreatment dramatically decreased the neuronal apoptosis and improved the survival rate in CA zebrafish.”
“Thiopental, midazolam, and ketamine attenuate CCE primarily via the TK signaling pathway.”
“Thiopental, midazolam, ketamine , and propofol each attenuated both peak and sustained CCE.”
“However, only ketamine (1 microM) inhibited NMDA-evoked elevation of intracellular calcium.”
Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation“We, therefore, conclude that ketamine has two effects on Ca2+ transport in isolated pulmonary artery smooth muscle: 1) it inhibits Ca2+ influx, and 2) it stimulates Ca2+-ATPase to cause efflux.”
“It is concluded that, in this model of closed cranial impact, 180 mg/kg of ketamine given 1 or 2 h after injury reduced both the increase in brain tissue calcium and the decrease in brain tissue magnesium at 48 h following head trauma.”
“In concentration-response curves, ketamine produced an insurmountable inhibition of contractions produced by KCl and the L-type Ca2+ channel agonist, Bay k 8644.”
“Conclusions:These findings indicate that the direct negative inotropic effect of ketamine results from a decrease in intracellular Ca++ availability with no changes in myofibrillar Ca++ sensitivity.”
“However, the phasic contraction produced by NE with 2mM lanthanum pretreatment, which is release of intracellular calcium , was also inhibited by ketamine.”
“Moreover, the tonic contraction produced by NE after depletion of the agonist-releasable pool of intracellular calcium , which is thought to be due to calcium influx, was depressed by ketamine.”
“Preincubation with ketamine produced a concentration-dependent inhibition of contractile responses elicited by the addition of calcium ion (1.6 mM) to a Ca(++)-free depolarizing solution.”
“Spontaneous epileptiform activity occurring in low calcium can be blocked by ketamine only when some synaptic transmission is still present.”
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