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Last Updated: 2 years ago

Possible Interaction: Kaempferol and Interleukin-10

supplement:

Kaempferol

Research Papers that Mention the Interaction

In addition, luteolin inhibits LPS-induced liver inflammation by inhibiting the production of inflammation-related gene tumor necrosis factor-α (TNF-α), IL-10 , and IL-6.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2021  |  View Paper
At this time, luteolin upregulated the level of IL-10 in serum and BALF and the frequency of CD4+CD25+FOXP3+ Tregs in PBMCs and splenic mononuclear cells of CLP mice.
In vitro, administration of luteolin significantly induced Treg differentiation, and IL-10 promoted the polarization of M2 macrophages but reduced the polarization of M1 macrophages.
Journal of immunology research  •  2021  |  View Paper
In contrast, luteolin significantly increased IL‐10 and IFN‐&ggr; protein levels, as well as IL‐10 and TGF‐&bgr;1 mRNA expression in the lung.
European journal of pharmacology  •  2018  |  View Paper
Furthermore, increase in IL-10 secretion after administration of kaempferol and resveratrol were observed.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2017  |  View Paper
We also found that luteolin and quercetin are able to stimulate the expression of the anti-inflammatory cytokine IL-10 at low concentrations (<50microM).
Biochemical pharmacology  •  2006  |  View Paper
Furthermore, Kae pretreatment decreased the levels of IL-1β, IL-6, and TNF-α and downregulated transcription of an array of inflammatory signaling molecules, while it increased IL-10 mRNA expression.
Frontiers in Immunology  •  2021  |  View Paper
Treatment with 30 ≤M luteolin significantly induced IL-8 expression at the mRNA and protein level, and the mRNA expression levels of IL-10 and NF-κB compared with the control.
Biomedical reports  •  2021  |  View Paper
LUT administration also reduced TNF-α and IL-10 mRNA expression in lung tissue.
Biotechnic & histochemistry : official publication of the Biological Stain Commission  •  2020  |  View Paper
Conclusion: LUT and CGA, which are abundant in LJF that is one of the ingredients in Gingyo-san, have adaptive immunoregulative effect on the expression of IL-10.
Ci ji yi xue za zhi = Tzu-chi medical journal  •  2019  |  View Paper
Furthermore, 2 μM luteolin pretreatment enhanced the expression of M2 macrophage markers (Arg-1 and IL-10 ), and decreased the expression of markers associated with M1 macrophage polarization (TNF-α, IL-6 and iNOS).
American journal of translational research  •  2018  |  View Paper