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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Kaempferol
drug:
Ici 182780
Research Papers that Mention the Interaction
“Kaempferol mediated activation of WNT signaling pathway through estrogen signaling pathway, as the application of ICI 182,780 (an inhibitor for estrogen receptors) markedly inhibited kaempferol-induced WNT signaling activation and osteogenic marker like ALP activity in SaOS-2 cells.”
Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts.“Interestingly preincubation with the estrogen receptor alpha antagonist ICI 182,780 (1 microM) prior to kaempferol partially reverted the antiapoptotic effect of this flavonoid on caspase-3 activation and DNA fragmentation induced by 7beta-hydroxycholesterol.”
Kaempferol inhibits apoptosis in vascular smooth muscle induced by a component of oxidized LDL.
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