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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Kaempferol
Research Papers that Mention the Interaction
“In vitro, Lu at dose less than 100 microM had only slight effect on cells growth and cytotoxicity of Dox in 4T1 and MCF-7 cells under normoxia, but it could reverse tumor resistance to Dox and promote death of tumor cells under hypoxia.”
Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells.“Focusing on the proliferative effect at low concentrations, we showed that luteolin has a cytoprotective effect on MCF-7 cells when administered with doxorubicin.”
“Moreover, luteolin attenuated doxorubicin-induced cytotoxicity even in the presence of the estrogen receptor (ER) antagonist ICI 182,780 and the ER-negative MDA-MB-453 human breast cancer cell line.”
“At physiological concentrations, luteolin significantly sensitized A549 cells to the anticancer drugs oxaliplatin, bleomycin, and doxorubicin.”
“Because the toxic effect of both kaempferol and doxorubicin was amplified when used in combination, this study raises the possibility of combinatorial therapy whose basis constitutes enhancing redox perturbation as a strategy to kill glioma cells. [”
“Importantly, kaempferol potentiated the toxic effect of chemotherapeutic agent doxorubicin by amplifying ROS toxicity and decreasing the efflux of doxorubicin.”
“Three inhibitors of tyrosine kinases (genistein, kaempferol , and quercetin) can inhibit the in vitro generation of ADR activity.”
“The combination of alpha G-Rutin and luteolin with DOX significantly inhibited the DOX induced-increment of the lipid peroxide level in bone marrow cells.”
Protective effect of flavonoids on doxorubicin-induced cardiotoxicity.“The combination of KF and doxorubicin revealed a stronger inhibitive effect on the viability of liver cancer cells.”
Kaempferol exhibits a synergistic effect with doxorubicin to inhibit proliferation, migration, and invasion of liver cancer“Therefore, luteolin can act as a chemoprotective agent in abating toxicities associated with doxorubicin usage and improve its therapeutic efficacy.”
“ LUT inhibited the activity of phlpp1 leading to positive regulation of the AKT/Bcl-2 pathway, which attenuated doxorubicin-induced cardiotoxicity.”
“Furthermore, luteolin attenuated doxorubicin-induced cardiotoxicity through promoting mitochondrial autophagy in association with facilitating phosphorylation of Drp1 at Ser616, and upregulating TFEB expression.”
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