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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Kaempferol
drug:
Celecoxib
Research Papers that Mention the Interaction
“Although our previous study demonstrated that the combination of celecoxib and luteolin synergistically inhibits breast tumor growth compared with each of the treatments alone, we did not uncover the molecular mechanisms of these effects.”
“The synergistic effects of a celecoxib and luteolin combination treatment yielded significantly greater cell growth inhibition in all four breast cancer cell lines compared with the single agents alone.”
“The celecoxib and luteolin combination treatment induced synergistic effects via Akt inactivation and extracellular signal-regulated kinase (ERK) signaling inhibition in MCF-7 and MCF7/HER18 cells and via Akt inactivation and ERK signaling activation in MDA-MB-231 and SkBr3 cells.”
“These results demonstrate the synergistic anti-tumor effect of the celecoxib and luteolin combination treatment in different four breast cancer cell lines, thus introducing the possibility of this combination as a new treatment modality.”
Synergistic effect between celecoxib and luteolin is dependent on estrogen receptor in human breast cancer cells“Decreased levels of Akt phosphorylation (pAkt) were noted after celecoxib and luteolin combination treatment.”
“In the past decade, several studies have demonstrated the antitumor effect of celecoxib and luteolin in breast cancer as single treatment.”
“The combination of celecoxib and luteolin provided superior inhibition of breast cancer cell growth than either celecoxib or luteolin treatment alone.”
“Although our previous study demonstrated that the combination of celecoxib and luteolin synergistically inhibits breast tumor growth compared with each of the treatments alone, we did not uncover the molecular mechanisms of these effects.”
“RESULTS The synergistic effects of a ce ecoxib an d lut eolin co mbination treatment yielded significantly greater cell growth inhibition in all four breast cancer cell lines compared with the single agents alone.”
“The celecoxib and luteolin combination treatment induced synergistic effects via Akt inactivation and extracellular signal-regulated kinase (ERK) signaling inhibition in MCF-7 and MCF7/HER18 cells and via Akt inactivation and ERK signaling activation in MDA-MB-231 and SkBr3 cells.”
The synergistic effect between celecoxib and luteolin and dependence on estrogen receptor in human breast cancer cells.
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