Possible Interaction: Kaempferol and Apigenin

“The cytotoxic potency of luteolin was higher than that of apigenin.”

“The interactive effects of these analogs with apigenin were further assessed by combining each analog at doses from … was found to double the proportion of SW480 cells in G2/M. When either acacetin, chrysin, luteolin, … apigenin at 20 μM, there was an increase … μM apigenin alone (P < 0.05).”

“The levels of MMP-13, MMP-3, TNF-α, IL-1β, iNOS were significantly decreased in the … of OA + MSCs + A0.1 μM + K10 μM and OA + MSCs + K20 μM. Co-treatment of kaempferol and apigenin increased the gene expression levels of collagen IIa1, aggrecan and SOX-9 genes.”

“At a dose of 10 μM apigenin , luteolin, naringenin, hesperidin, quercetin and kaempferol induced significant reductions, and at 1 μM only naringenin, hesperidin and quercetin were effective.”

“The pretreatment with apigenin and luteolin significantly prevented the decrease in C2C12 myotube diameter caused by LPS stimulation.”

“…,kaempferol and epicatechin are potent inhibitors of H₂O₂ production by mitochondria from both tissues (IC₅₀ approximately 1-2 μM), even when H₂O₂ … A. Although the rate of oxygen consumption was unaffected by concentrations up to 10 μM of these flavonoids, quercetin, kaempferol and apigenin inhibited complex I … 20% inhibition.”

“ Luteolin significantly inhibits insulin-stimulated phosphorylation of insulin receptor-beta subunit (IR-beta), and apigenin , kaempferol, quercetin and fisetin, also tended to inhibit the IR-beta phosphorylation.”

“Their innocuousness appeared to be related to glycosylation, because the corresponding aglycones (naringenin, eriodictyol, hesperetin, apigenin, kaempferol ) were all inhibitory, in particular apigenin (80% inhibition at 100 μM).”

“Among three flavonoids contained in AF-08, apigenin and chrysin obviously inhibited platelet aggregation but the inhibitory effect of kaempferol was less effective.”