“Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (and/or …) of alprazolam, amitriptyline, atorvastatin, chlorzoxazone, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine , mephenytoin, methadone, midazolam, nifedipine, omeprazole, oral …, tacrolimus, talinolol, verapamil, voriconazole and warfarin.”