Possible Interaction: Isotretinoin and Vitamin A

“The placebo group (N = 38) had little change, whereas the 13-cis-retinoic acid group , (N = 35) experienced a decline in retinol levels (p = 0.06).”

“ All-trans-RA reduced the yield of HSV-1 by 100-fold at 5 micrograms/ml but 9-cis-RA and 13-cis-RA reduced viral replication by 10-fold.”

“As shown previously, vitamin A intake via liver consumption resulted in greatly increased plasma levels of 13-cis-retinoic acid (13-cis-RA) and 13-cis-4-oxo-RA, and low levels of all-trans-RA and all-trans-4-oxo-RA.”

“However, since isotretinoin is closely related chemically to the naturally occurring retinoids (retinol, retinoic acid), it is … drug may interfere with the endogenous metabolism of vitamin A. To study the possible interaction of isotretinoin … vitamin A at the target level we investigated 22 …-41 years) with severe nodulocystic acne.”

“Furthermore, and on a theoretical basis only so far, I suggest that the prohibition of vitamin A supplements during isotretinoin and other retinoid therapies may be counterproductive.”

“Furthermore, and on a theoretical basis only so far, I suggest that the prohibition of vitamin A supplements during isotretinoin and other retinoid therapies may be counterproductive.”

“Furthermore, and on a theoretical basis only so far, I suggest that the prohibition of vitamin A supplements during isotretinoin and other retinoid therapies may be counterproductive.”

“In vitro evidence suggests isotretinoin may interfere with the processing of endogenous vitamin A in the retina.”

“For the most bioavailable formulation used in the supplement study, daily ingestion of 5,000 IU of vitamin A caused increases of 141 ± 53% and 171 ± 77% from baseline in the 24‐hour AUCs of isotretinoin and 4‐oxo‐isotretinoin, respectively.”

“For example, the anti-acne drug, isotretinoin , lacks affinity for the receptors, but is a very potent inhibitor of endogenous vitamin A metabolism in human epidermal cells.”