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Last Updated: 2 years ago

Possible Interaction: Isotretinoin and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

In contrast, dosing with 13-cis-RA yielded much higher plasma retinoid levels.
Drug metabolism and disposition: the biological fate of chemicals  •  1995  |  View Paper
It is a very effective agent in a treatment of acne vulgaris; however, multiple side effects related to therapy with retinoids preclude the use of isotretinoin in less severe acne vulgaris.
Cutaneous and ocular toxicology  •  2017  |  View Paper
The elimination half-life of 13-cis-retinoic acid was about 1.5 hr while the elimination half-life of all-trans-retinoic acid was slightly longer.
Basic & clinical pharmacology & toxicology  •  2006  |  View Paper
With respect to structure-activity relationships, retinol appears to have less than 1/4 the potency of all-trans retinoic acid, and isotretinoin may have much less than 1/8 the potency of all-trans retinoic acid in disrupting development with respect to all endpoints.
Neurotoxicology and teratology  •  1993  |  View Paper
There was significant growth inhibition after treatment with retinoic acid and 13-cis-retinoic acid.
Nutrition and cancer  •  1990  |  View Paper
As the number of patients treated by 13-cis-retinoic acid increases, demands for salvage treatment after systemic retinoid therapy are emerging.
BMC Musculoskeletal Disorders  •  2019  |  View Paper
Retinoic acid can increase AQP3 expression in HaCaT cells, with significant effects observed with 0.010 mg/mL isotretinoin treatment for 12 h. The side effects, namely skin and mucosa dryness caused by retinoic acid might be related to its effects on AQP3 expression.
Genetics and molecular research : GMR  •  2016  |  View Paper
Combined treatment with 13-cis retinoic acid augmented these effects and enhanced activation of retinoic acid signaling.
Chemistry & biology  •  2013  |  View Paper
Although naturally occurring mutations in the retinoic acid pathway are not preventable, preventing teratogenicity from the use of oral isotretinoin is a priority formany different groups: patients, physicians, the Food and Drug Administration (FDA), and numerous others who have vested interests.
Pediatric dermatology  •  2012  |  View Paper
The combination of GSIs and 13-cis RA resulted in the enhanced growth inhibition, differentiation, and migration of neuroblastoma cells.
Neuro-oncology  •  2010  |  View Paper
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