Possible Interaction: Isotretinoin and Tretinoin

“In contrast, dosing with 13-cis-RA yielded much higher plasma retinoid levels.”

“It is a very effective agent in a treatment of acne vulgaris; however, multiple side effects related to therapy with retinoids preclude the use of isotretinoin in less severe acne vulgaris.”

“The elimination half-life of 13-cis-retinoic acid was about 1.5 hr while the elimination half-life of all-trans-retinoic acid was slightly longer.”

“With respect to structure-activity relationships, retinol appears to have less than 1/4 the potency of all-trans retinoic acid, and isotretinoin may have much less than 1/8 the potency of all-trans retinoic acid in disrupting development with respect to all endpoints.”

“There was significant growth inhibition after treatment with retinoic acid and 13-cis-retinoic acid.”

“As the number of patients treated by 13-cis-retinoic acid increases, demands for salvage treatment after systemic retinoid therapy are emerging.”

“ Retinoic acid can increase AQP3 expression in HaCaT cells, with significant effects observed with 0.010 mg/mL isotretinoin treatment for 12 h. The side effects, namely skin and mucosa dryness caused by retinoic acid might be related to its effects on AQP3 expression.”

“Combined treatment with 13-cis retinoic acid augmented these effects and enhanced activation of retinoic acid signaling.”

“Although naturally occurring mutations in the retinoic acid pathway are not preventable, preventing teratogenicity from the use of oral isotretinoin is a priority formany different groups: patients, physicians, the Food and Drug Administration (FDA), and numerous others who have vested interests.”

“The combination of GSIs and 13-cis RA resulted in the enhanced growth inhibition, differentiation, and migration of neuroblastoma cells.”