supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Isotretinoin
supplement:
Retinyl Palmitate
Research Papers that Mention the Interaction
“In contrast, single … doses of RP at 10,000 IU or 30,000 IU produced dose-related and sustained increases in Cmax and AUC0-24 h values of plasma RP, RO, RS, 13-cis- and 13-cis-4-oxo-RAs, as well as a transient increase in AT-RA.”
Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age.“Treatment with retinyl palmitate significantly increased the serum concentration of retinyl palmitate and of 13-cisretinoic acid but not of retinol, tocopherol or all-trans-retinoic acid. •”
“Our investigation was conducted to determine whether vitamin A retinyl palmitate ) supplementation significantly increases circulating RA concentrations of all-trans-, 9-cis-, and 13-cis-RA.”
“We have demonstrated that micromolar concentrations of HPR, retinoic acid, 13-cis-retinoic acid or Acitretin significantly reduced the in vitro hydrolysis of retinyl palmitate.”
Multiple retinoids alter liver bile salt-independent retinyl ester-hydrolase activity, serum vitamin A and serum retinol-binding protein of rats.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback