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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isotretinoin
supplement:
Mannose
Research Papers that Mention the Interaction
“ 13-cis-Retinoic acid , a drug used at high doses in the treatment of recalcitrant acne, increased the permeability of rat-liver microsomal membranes to mannose 6-phosphate in vitro, as indicated by an increase in mannose-6-phosphatase activity.”
13-cis-retinoic acid stimulates in vitro mannose 6-phosphate hydrolysis and inhibits retinol esterification and benzo[a]pyrene hydroxylation by rat-liver microsomes.
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