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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Isothiocyanate
supplement:
Sulforaphane
Research Papers that Mention the Interaction
“Its isothiocyanate group renders SFN reactive, thus allowing post-translational modification of cellular proteins to regulate their function with the potential for biological and therapeutic actions.”
Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue“Herein, we tested the hypothesis that combination of two isothiocyanates, i.e. allyl isothiocyanate and sulforaphane , produced a synergy in inhibiting the growth of A549 lung cancer cells.”
“Moreover, a synergy between allyl isothiocyanate and sulforaphane was also observed in anti-cell migration.”
“The structure-activity relationship revealed an inhibitory potency of methylsulfinyl isothiocyanate dependent on the alkyl chain length and the sulfoxide, sulfone, and/or the isothiocyanate moiety.”
“Exposure of Nrf2(+/+) fibroblasts, … chemopreventive agent sulforaphane Sul) … isothiocyanate , caused an induction of between 2- and 10-fold in the levels of mRNA for glutamate-cysteine ligase catalytic (Gclc) … oxidoreductase-1 (Nqo1); this was accompanied by an increase in total glutathione of between 1.5- and 1.9-fold.”
The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.
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