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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Isothiocyanate
Research Papers that Mention the Interaction
“ Isothiocyanates (ITCs) play a major role in the potential chemopreventive effect.”
Methallyl isothiocyanate inhibits the caspase-1 activity through the inhibition of intracellular calcium levels.“Exposure of …) of the chemopreventive agent sulforaphane (… the isothiocyanate , caused an induction of between 2- and 10-fold in the levels of mRNA for glutamate-cysteine ligase catalytic (Gclc) … oxidoreductase-1 (Nqo1); this was accompanied by an increase in total glutathione of between 1.5- and 1.9-fold.”
The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.
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