Possible Interaction: Isoproterenol and Tyrosine

“This tyrosine phosphorylation is maximal within 5 min of isoproterenol stimulation and reaches values of ∼5-fold over basal conditions.”

“Here, we demonstrate that the β‐AR agonist isoproterenol potently evokes the tyrosine phosphorylation of STAT3 and increases its transcriptional activity in an extracellularly regulated kinase 1/2 and glycoprotein (gp)130 signaling‐dependent manner in rat cardiomyocytes.”

“ Isoproterenol markedly inhibited the effect of insulin on the phosphorylation of the three tyrosines from the kinase domain.”

“ Isoproterenol (10 mumol/kg) caused significant increases in aromatic amino acid ( tyrosine , phenylalanine and tryptophan) levels in cerebral cortex and decreases in almost all amino acid concentrations in plasma.”

“This effect of isoproterenol on brain tyrosine level was dose-dependent with an ED50 of 0.25 mumol/kg.”

“ Isoprenaline given to rats in doses between 0.08 and 10 mg/kg intraperitoneally caused a significant decrease in plasma concentrations of tyrosine and tryptophan.”

“Stimulation of adenylate cyclase activity by either L-isoproterenol , glucagon, prostaglandin Ei, prostaglandin E2 or cholera toxin produced a 23–43% decrease in tyrosine release rate.”