Possible Interaction: Isoproterenol and Taurine

“In conclusion, the present study demonstrated that taurine could inhibit the injury induced by ISO by increasing myocardial negative inotropic effect and antioxidant ability, decreasing the hypertrophic response to isoproterenol and protecting the integrity of -myocardial ultrastructure, decreasing myocardial leak of CK-MB.”

“The results showed that taurine could significantly prevent the increase of heart coefficient induced by ISO.”

“The ultrastructure of cardiomyocytes showed that taurine administration could significantly reverse the injury caused by ISO.”

“ Isoproterenol depressed similarly the taurine uptake in cells incubated in CIM or KR.”

“In addition to SP, isoproterenol , a beta-adrenergic agonist, can also increase the release of [3H]taurine from these cells and the effects of SP and isoproterenol were additive.”

“Parenteral administration of taurine (200 mg/day for 7 days) partially protected against these necrotic changes induced by isoprenaline.”

“Intraperitoneal administration of taurine significantly prevented the isoprenaline‐induced increases in the levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase in the plasma of rats.”

“Oral administration of taurine (200 mg.kg-1 for seven days) partially protected against these changes induced by isoprenaline.”

“ Taurine (10 mM) not only failed to induce slow APs, but actually decreased ISO (10(-8) M), HIS (10(-4) M), or TEA (10 mM) induced slow APs and contractions transiently (about 30s-2 min after the addition of taurine).”

“ Isoproterenol (4 X 10(-7) M) stimulated the rate of taurine influx, but propranolol (1 X 10(-8) M) blocked this stimulation.”

“Administration of the beta-agonist isoproterenol to rats caused a sharp increase in the influx rate of taurine into the heart, but had no effect on the rate of biosynthesis of taurine in the heart.”

“When taurine release was stimulated with a saturating concentration of isoproterenol , the inactivation of release was significantly faster than the decline of intracellular cAMP.”