“Our results show … myocytes, S1P (100 nM) does not affect the basal activity of ICa,L … to partially reverse the effect of the β-adrenergic agonist Isoproterenol (ISO, 100 nM) on ICa,L. S1P (25 nM) also significantly … nM)-induced Ca2+ waves and diastolic Ca2+ release in these cells.”