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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoproterenol
supplement:
Progesterone
Research Papers that Mention the Interaction
“In primary cultures of porcine granulosa cells incubation with isoproterenol (10(-7)-10(-5) M) produced a dose-dependent increase in 3 beta-HSD mRNA, 3 beta-HSD content and progesterone production which ranged from 1.5- to 5-fold.”
Alterations in 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) mRNA accumulation induced by beta-adrenergic stimulation in cultured porcine granulosa cells.“Stimulation of granulosa cells with luteinizing hormone or the β-agonist isoproterenol increased the release of progesterone after 4 d in culture.”
“Estrogen treatment alone or in combination with progesterone reduced maximal relaxation (E(max)) of isolated uterine strips subsequently challenged with isoproterenol whereas progesterone alone had no effect on this parameter.”
Desensitization of beta2-adrenoceptor function in non-pregnant rat myometrium is modulated by sex steroids.“Finally, when isoproterenol infusions were given in combination with both oestrogen and progesterone , PGF(2alpha)-R mRNA and E(max )were enhanced as compared with similar rats not having received isoproterenol.”
“ Isoproterenol , a potent adrenergic agent, stimulated both cAMP accumulation and progesterone production in these cells in a dose dependent manner.”
“However, OTRs were induced at the level of gene expression when progesterone was supplemented with isoproterenol infusion.”
“ Progesterone decreased both cAMP levels and lipolysis in quiescent adipocytes or in adipocytes stimulated by isoproterenol.”
“DA, norepinephrine (NE) and isoproterenol (Iso) increased the levels of progesterone (P4) and cAMP in the media.”
“ Progesterone accumulation induced by LH or isoproterenol was synergistically augmentated by the simultaneous presence of both inducers.”
“The stimulatory effect of isoproterenol on cyclic AMP and progesterone production was significantly higher (P< 0.05) than that of LH.”
“ Isoproterenol caused a generalized inhibition of LH‐stimulated steroidogenesis, decreasing the accumulation of pregnenolone, progesterone , androstenedione and estradiol in the culture medium.”
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