Possible Interaction: Isoproterenol and Potassium

“ Isoprenaline and salbutamol decreased plasma potassium dose-dependently.”

“ Isoproterenol (4 × 10 −10-4 × 10 −6 M) concentration dependently relaxed the strips under potassium contracture , but a high dose (4 × 10−5 M) constricted them.”

“Using a triple lumen perfusion technique we have demonstrated that intravenous isoproterenol significantly increased absorption of sodium, chloride, and water in both the jejunum and ileum, and of potassium in the ileum.”

“Sustained isoproterenol exposure decreased IKs density (whole cell patch clamp) by 58% (P<0.0001), with corresponding decreases in potassium voltage-gated channel subfamily E member 1 (KCNE1) mRNA and membrane protein expression (by 45% and 51%, respectively).”

“In this model of mucosal injury, pretreatment with prostaglandin E2 or isoproterenol significantly and dose dependently decreased luminal hydrogen loss, potassium gain , and DNA accumulation in both shocked and normotensive animals.”

“In conscious rabbits the intravenous infusion of adrenaline (0.3 microgram kg-1 min-1), noradrenaline (1 microgram kg-1 min-1) or isoprenaline (1.25 micrograms kg-1 min-1) caused a significant decrease in plasma potassium levels.”

“Also, isoprenaline was less potent and efficacious on aortic strips contracted with potassium than on strips contracted with phenylephrine.”

“ Isoproterenol at the dosage of 5 μg/kg body wt significantly inhibited net influx of potassium in both the RES rat and normal rat.”

“ Isoproterenol (0.6-0.8 microgram/min), a nonspecific beta-agonist, reduced coronary sinus potassium concentration transiently to a nadir of 0.28 (0.15-0.43) mM (median and 95% confidence interval) below control values (n = 12).”

“ Spontaneous potassium release from the slices was significantly inhibited by isoproterenol at concentrations above 10(-6) M. This isoproterenol effect was completely abolished in the presence of propranolol (10(-5) M) and ouabain (10(-3) M) and was abolished during Na+-exclusion from the incubation medium.”

“The stimulatory effect of isoproterenol on the Na+, K+-ATPase exhibited a strong correlation with the inhibition of potassium release on each dose of isoproterenol.”

“These results suggest that the inhibitory effect of isoproterenol on potassium release is clearly derived from the elevated Na+, K+-ATPase activity and that it may in part be mediated by cyclic AMP.”