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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoproterenol
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“The relative amounts of various polyunsaturated fatty acids in cardiac lipids influence markedly the development of myocardial necrosis and mortality following overstimulation with isoproterenol.”
The role of myocardial membrane lipids in the development of cardiac necrosis.“Findings suggest that PUFA modulates plasma and melatonin aortic NO levels of isoproterenol affected rats in a strain-dependent manner.”
Modulation of systemic and aortic nitric oxide by melatonin and n-3 polyunsaturated fatty acids in isoproterenol affected spontaneously hypertensive and normotensive Wistar rats.“It has been found … of ω-3 PUFA (Epadol 0.1 ml/100 gr of weight for 4 weeks) significantly reduced the swelling of subsarcolemmal and interfibrillar mitochondrial ….52% 54.84% respectively, pointing for a decrease of damage of the mitochondrial function evoked by in vivo administration of isoproterenol.”
“… polyunsaturated fatty acids (5-10 microM), especially the fish oil omega-3 fatty acids, but … were able to effectively prevent and terminate the arrhythmias induced by isoproterenol (as well as by cAMP and cholera toxin) without affecting the … action was independent of their metabolites and incorporation into membrane phospholipid.”
“At the same time the excess of dietary polyunsaturated fatty acids resulted in enhanced vasodilatory responses to isoproterenol and acetylcholine.”
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