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Last Updated: 5 years ago
drug:
Isoproterenol
supplement:
Oxytocin
Research Papers that Mention the Interaction
“ OT counteracted the isoprenaline , i.e. the beta-adrenoceptor/Gs-mediated effect in NPM cells measured in OAP.”
Oxytocin receptors differentially signal via Gq and Gi proteins in pregnant and nonpregnant rat uterine myocytes: implications for myometrial contractility.“However, HR in TAC + OXT animals increased to match Control at higher doses of isoproterenol.”
“The response of TAC and TAC + OXT hearts to isoproterenol was blunted, with no significant increase in RPP, contractility, or relaxation.”
Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure“ Isoproterenol reduced inositol phosphate response to carbachol and oxytocin to an amount equivalent to that elicited by oxodipine.”
“The inhibitory effect of isoproterenol on both inositol phosphate accumulation and [Ca++]i increase induced by oxytocin was abolished by pertussis toxin.”
“The neurohypophysial oxytocin storage was diminished by a single dose of isoprenaline ; on the contrary, during dehydration isoprenaline distinctly intensified the oxytocin depletion in the neurohypophysis.”
“ Isoproterenol similarly had little effect on basal but inhibited oxytocin stimulation of phosphoinositide breakdown.”
“The OT release induced by suckling in both sham-operated and adrenal demedullated rats was prevented by stimulation of beta-adrenergic receptors with isoproterenol.”
“ Oxytocin inhibited the incorporation of [Me-3H]choline into phosphatidylcholine in both the presence and the absence of isoprenaline , whereas in the absence of isoprenaline insulin increased the incorporation of [Me-3H]choline into phosphatidylcholine.”
“The stimulatory effect of isoprenaline was inhibited in a dose-dependent manner by oxytocin or insulin.”
“The effects of oxytocin were inhibited by insulin and were additive with those of isoproterenol on PLMT.”
“Graded concentrations of salbutamol, isoproterenol , papaverine, theophylline, thioglycollate, and MgCl2 produced a decrease in the maximal effect of oxytocin and a shift of the concentration-effect curves to the right.”
“Salbutamol and isoproterenol appeared to act as functional antagonists of oxytocin in which agonist and antagonist each interacted with its own specific receptor to produce a decreased combined effect on a common effector.”
“On the other hand, the upregulation of Cav1.2 mRNA expression by isoproterenol is halted by OT.”
Oxytocin Downregulates the CaV1.2 L-Type Ca2+ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes
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