Possible Interaction: Isoproterenol and Melatonin

“ Isoproterenol , a β-adrenergic stimulant, significantly increased melatonin content, although the increase was smaller in Cry1−/−/Cry2−/− than in WT mice, during both the day and night.”

“A histological analysis revealed that chronic intake of MEL diminished the age-dependent changes in the structure of muscle fibers of the left ventricle, muscle fiber swelling, and injury zones characteristic of acute cardiac failure caused by ISO.”

“ MEL partially prevented ISO-induced changes at the subunit level of respiratory complexes III and V and drastically decreased the expression of complex I subunit NDUFB8 both in control RHM and in RHM treated with ISO , which led to the inhibition of ROS production.”

“ MEL prevents the mitochondrial dysfunction associated with heart failure caused by ISO.”

“ Melatonin , a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol.”

“ Isoproterenol stimulated (P<0.01) melatonin secretion compared with values observed during the pretreatment period.”

“Results of the present study suggest that melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities.”

“The results showed that melatonin (50 μm) caused a significant reduction in both isoproterenol (10−7 m) and forskolin (10−6 m) induced cAMP production and that both these responses were melatonin receptor dependent, since the blocker, luzindole (5 × 10−6 m) abolished this effect.”

“ Melatonin significantly reduced the increase in contractile force in response to isoproterenol , both when present and after melatonin-washout.”

“ Isoproterenol stimulated melatonin production in both young and old rat pineal glands, whatever the circadian stage.”

“Conclusion These results suggest that NAC and melatonin decreased the MAP and heart rate and improved the chronotropic response to isoproterenol in SHRs, in association with an inhibition of sympathetic activity and the restoration of cardiac β-adrenoceptor function.”

“Administration of the beta-adrenergic agonist isoproterenol (20 mg/kg) 2 and 4 h after lights on in the morning resulted in a fivefold increase in plasma and pineal melatonin 2.5 to 3 h after the first injection.”