Possible Interaction: Isoproterenol and Magnesium

“A large dose of isoproterenol increased serum lipid peroxide levels and serological markers of myocardial damage, which were significantly suppressed by magnesium.”

“ Magnesium significantly attenuated isoproterenol-induced LV systolic and diastolic dysfunction and preserved the dose response to isoproterenol.”

“In the present study using rat cerebral cortex, we determined that magnesium can reverse the ability of lithium to inhibit isoprenaline- and carbamylcholine-induced increases in guanosine triphosphate (GTP) binding to G proteins.”

“The activating effect of magnesium and sodium ions was accompanied by the attenuation of the enzyme sensitivity to NaF, guanylyl imidodiphosphate and isoproterenol.”

“N‐Acetyltransferase (NAT) activity at night and following isoproterenol treatment in intact animals was higher in rats pretreated with magnesium than in controls.”

“ Isoproterenol , a beta-adrenergic agonist, stimulates magnesium uptake only minimally.”

“ Magnesium in the medium enhanced the degree of reserpine-induced supersensitivity to isoproterenol in whole aortic strips.”

“The decrease in sensitivity to isoproterenol in the presence of magnesium might be the result of its effect on calcium movements at the membrane and/or at intracellular calcium binding sites.”

“The potentiating effect on the contractile tension responses to isoproterenol by magnesium might be a result of an increase in the amount of available calcium or to conformational changes produced on the membrane leading to a change in the contractility of the cells.”

“It was found, further, that isoproterenol consistently caused an alteration of the total myocardial electrolyte content in DCA-saline-treated rats, consisting of a decrease of magnesium ( Mg ) and potassium (K) levels and elevation of sodium (Na).”