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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoproterenol
supplement:
Linoleic Acid
Research Papers that Mention the Interaction
“In contrast, whilst both isoprenaline and PGE2-stimulated adenylate cyclase activities showed similar break-points in their Arrhenius plots, dietary linoleic acid manipulation markedly altered their form.”
Dietary linoleic acid-induced changes in respiratory beta-adrenergic receptor function and the form of arrhenius plots of isoprenaline- and prostaglandin E2-stimulated adenylate cyclase activity in a model for atopy.“In rat parotid gland, chronic administration of isoproterenol caused significant increase of linoleic acid and decrease of arachidonic acid at the sn-2 position of phosphatidylcholine.”
“The inotropic and chronotropic effects of isoprenaline (100 ng) in isolated perfused hearts were reduced after a linoleic acid rich diet by 36% and 51%, respectively, with an accompanying reduction in isoprenaline-induced increase in the ventricular cAMP content.”
“In isolated perfused hearts of rats fed on a diet rich in LA for a 10-week period the inotropic effects of isoprenaline were diminished, whereas the isoprenaline-induced increase in coronary flow rate was augmented.”
“The mechanisms by which dietary LA influences cardiac function and the effectiveness of isoprenaline remain unclear.”
“Simultaneously the LA rich diet reduced the heart rate increase and the positive inotropic effect of isoprenaline without changing the increase in the coronary flow and without any effect on the heart performance of coronary vasodilators like oxyfedrine and prenylamine.”
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