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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoproterenol
supplement:
Leucine
Research Papers that Mention the Interaction
“ Isoproterenol application enhanced and largely resynchronized SR Ca(2+) release, while it increased the magnitude and shortened the time to peak of I(Ca, L).”
Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling.“Perfusion of isoproterenol (1 μM) significantly increased the peak ICa, L by 515 ± 44% in 6 atrial myocytes from NF but increased only by 135 ± 25% in 27 atrial myocytes from FH.”
“Isoproterenol ISO ) increased I(Ca, L ) approximately threefold and caused a negative shift in V(0.5) in control cells, but it did not increase I(Ca,L) in MbetaCD-treated myocytes, nor did it shift V(0.5).”
Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its -adrenergic enhancement in ventricular myocytes.“Finally, norepinephrine, isoproterenol , CL316243, and palmitate inhibited the effects of insulin, L-leucine , and L-glutamate on leptin synthesis.”
“ Isoproterenol increased I(Ca, L ) density more in the unafflicted anteroseptal group than in the other groups.”
“In euthyroid myocytes, 0.1 μM isoproterenol (Iso) increased ICa, L (at VM=0 mV) from −7.04±0.72 to −22.26±1.88 pA/pF, P<0.05, while in hyperthyroid myocytes (ICa, L=-21.48±2.94 pA/pF), Iso was ineffective.”
“In response to isoprenaline , the [3H]leucine incorporation increased by 79% in the parotid glands and by 82% in the submandibular glands.”
“In the absence of Ca(2+), isoproterenol severely reduced and slowed I(Ca, L ) inactivation; this effect was reversed by carbachol.”
“ET-1 (> or =10 nM) suppressed the basal ICa,L to 79+/-8% of control at 20 nM. Bath application of isoproterenol (ISO; 10 nM) enhanced ICa, L to 192+/-28% with about a -10-mV shift of its relationship with membrane potential.”
“In ventricular cells, isoproterenol (1 microM) increased the amplitude of not only the L but also the T currents; the latter effect probably was secondary to a rise in [Ca]i following the augmentation of the L current.”
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