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Last Updated: 3 years ago
drug:
Isoproterenol
supplement:
Genistein
Research Papers that Mention the Interaction
“After I(Ca) stimulation by genistein , external application of isoproterenol (1 microM) caused an additional increase in I(Ca).”
Tyrosine kinase and protein kinase C regulate L-type Ca(2+) current cooperatively in human atrial myocytes.“Treatment of genistein could suppress the expression of mitochondrial pro-apoptotic proteins including Bad, caspase-8, caspase-9, and caspase-3 in H9c2 treated with ISO.”
“The tyrosine kinase inhibitor, genistein , inhibited carbachol-induced contractions only in the presence of isoproterenol.”
“With genistein but not with T23, there is an enhanced sensitivity of ICaL to isoproterenol in both NZs and IZs but peak ICaL is not fully restored in IZs.”
“In rat aortic rings, genistein , an inhibitor of tyrosine kinase, but not daidzein, an inactive analogue of genistein, potentiated the relaxation induced by isoproterenol.”
“The potentiating effect of genistein on the relaxation induced by isoproterenol in the presence of ICI-118,551 was apparently greater than that in the presence of atenolol.”
“ GST (50 µM) reversibly increased ICl by nearly 50% in myocytes with Gs selectively activated by 1 µM ISO , and also reversibly increased the ICl that was persistently activated after withdrawal of ISO from GTPγS-dialysed myocytes.”
“Iberiotoxin, an inhibitor of Ca-activated K (KCa) channels, partly inhibited the isoproterenol-induced relaxation and the potentiating effect of genistein on the relaxation induced by isoproterenol.”
“Pretreatment of the aortic rings by genistein , but not by daidzein, an inactive analogue of genistein, potentiated the relaxation induced by isoproterenol.”
The potentiating effect of genistein on the relaxation induced by isoproterenol in rat aortic rings.“However, in the presence of a subthreshold concentration (1 nmol/L) of the beta-adrenergic agonist isoproterenol (Iso), genistein caused a near-maximal activation of this current.”
“In the absence of genistein, 1 nmol/L Iso had no effect on either IK or ICa-L. However, in the presence of genistein , 1 nmol/L Iso significantly increased the magnitude of both currents.”
Genistein increases the sensitivity of cardiac ion channels to beta-adrenergic receptor stimulation.“Amylase release stimulated by isoproterenol was dose‐dependently inhibited by genistein.”
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