Possible Interaction: Isoproterenol and Adrenocorticotropic Hormone

“Both non-specific (membrane depolarization with 45 mM KCl) and specific isoproterenol at 10(-7) M) stimulation increased the ACTH secretion from 10 to 20 pg/min/g to 60 to 80 pg/min/g.”

“The effects of isoproterenol on LDL receptor expression were mimicked by forskolin, by an analog of cyclic AMP, and by ACTH.”

“Administration of the beta-receptor agonist isoproterenol stimulated ACTH , beta-END, alpha-MSH and PRL two to five-fold.”

“The rates of secretion of both ANF and ACTH could be increased 3-5-fold with a variety of known AtT-20 cell secretagogues including phorbol esters and the beta-adrenergic agonist, isoproterenol , thus indicating that both peptides were routed through regulated secretory pathways.”

“ ACTH treatment was found to reduce the alpha adrenergic potentiation of isoproterenol- and 2-chloroadenosine-stimulated cyclic AMP production, as well as reduce the sensitivity of the norepinephrine response to prazosin.”

“In addition to diminishing beta-receptor responsiveness, (-) isoproterenol treatment induces a prolonged elevation of basal ACTH release.”

“VIP with either CRF or (−) isoproterenol produced additive increases in both cyclic AMP and ACTH secretion.”

“ isoproterenol induced a dose-dependent (10(-9)-10(-7) M), parallel increase in the release of alpha-MSH and ACTH following similar time courses and showing identical EC50 values (about 10(-8)M).”

“Thus, for example, exposure of adipocytes to isoproterenol desensitized them to further stimulation by both isoproterenol and ACTH.”

“Infusion of isoproterenol evoked an increase of the plasma levels of corticosterone, ACTHi , beta-ENDi and alpha-MSH immunoreactivity (alpha-MSHi) in sham-operated rats.”