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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoniazid
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“We have carried out a randomised clinical trial of a 12-month course of isoniazid plus vitamin B6 versus vitamin B6 alone in Port-au-Prince, Haiti, to assess the efficacy of isoniazid in preventing active tuberculosis in symptom-free HIV-infected individuals.”
Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection“1) The chronic administration of isoniazid for the prevention or treatment of tuberculosis can produce peripheral neuropathy which can be prevented by the concurrent administration of pyridoxine.”
“ Isoniazid , which prevents the formation of pyridoxal phosphate , produces an exactly similar pattern of denervation in rats and probably in man.”
“Adaptation of prescription – either with higher doses of pyridoxine or decreased doses of isoniazid, respectively – has been suggested to reduce the risk of potentially life-threatening toxicity of isoniazid.”
“ Isoniazid toxicity occurs in populations at risk, including patients with chronic kidney failure or NAT2 polymorphisms, who have a disturbed metabolism of pyridoxine or isoniazid, respectively, and those on renal replacement therapies, in whom pyridoxal phosphate – the active metabolite of pyridoxine – is inadvertently removed by dialysis.”
“In addition, PLP and pyridoxamine 5'-phosphate (PMP) reversed the cellular inhibition of hALAS2 activity by INH.”
“Steady-state kinetic analyses … hALAS2 indicated that INH directly inhibits the enzyme, noncompetitively or uncompetitively, with an apparent Ki of 1.2μM. Circular dichroism … revealed that INH triggered tertiary structural changes in hALAS2 that altered the microenvironment of the PLP cofactor and hampered the association … PLP with apo-hALAS2.”
“Both of them responded after stopping INH and increasing the dose of pyridoxine.”
“DSP can also occur in response to isoniazid INH ); this can be prevented by pyridoxine supplementation.”
“ Isoniazid though a very effective treatment for tuberculosis can cause severe motor-dominant neuropathy which can be reversible with pyridoxine supplementation.”
“In addition, three of the patients were offered oral pyridoxine 20 mg daily to prevent any neurological side effects of isoniazid.”
“But it must be remembered that each milligram of pyridoxine inactivates one milligram of INH.”
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