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Last Updated: 3 years ago

Possible Interaction: Isoniazid and Taurine

supplement:

Taurine

Research Papers that Mention the Interaction

The most significant decrease of the neurotoxic effect of isoniazid was observed with the use of taurine in a dose of 255 mg/kg.
The use of taurine lowered the toxic effect of isoniazid , evident from delayed covulsions, their shorter time, rarer repeat and lower mortality of the animals due to tonoclonic spasm.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]  •  2016  |  View Paper
Taurine (200 μmol L-1) and N-acetylcysteine (200 μmol L-1) effectively countered the toxic effects of isoniazid and/or hydrazine by decreasing ROS formation, lipid peroxidation, and mitochondrial damage.
This study suggests that the protective effects of taurine against isoniazid and its intermediary metabolite hydrazine cytotoxicity in rat hepatocytes could be attributed to antioxidative action.
Arhiv za higijenu rada i toksikologiju  •  2013  |  View Paper