supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Isoniazid
supplement:
Manganese Cation (2+)
Research Papers that Mention the Interaction
“A suggested mechanism involving autoxidation of INH … presence of a transition metal, Mn(II), … INH , (ii) cells stored for a long time in the refrigerator are much more sensitive to INH + Mn(… peroxidase activity, (iii) presence of S9 mix during the treatment eliminated the effect of INH + Mn(II).”
Mitotic gene conversion induced in yeast by isoniazid. influence of a transition metal and of the physiological conditions of the cells.“ Isoniazid , hydrazine, and phenylhydrazine induced DNA single- and double-strand breaks in cells pretreated with Mn(II) , whereas iproniazid did not.”
“With isolated 32P-DNA, isoniazid produced DNA damage in the presence of Cu(II), Mn(II ), or Mn(III).”
Manganese-mediated oxidative damage of cellular and isolated DNA by isoniazid and related hydrazines: non-Fenton-type hydroxyl radical formation.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback