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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoniazid
supplement:
Allyl Sulfide
Research Papers that Mention the Interaction
“Further more, rat primary hepatocytes survival rates decreased significantly in cultures treated with INH together with DAS than in cultures treated with INH alone after 24h.”
“Moreover, when hepatocytes were co-treated with INH and 1mM DAS , accelerated GSH depletion and increased ROS production appeared.”
Oxidative stress potentiated by diallylsulfide, a selective CYP2E1 inhibitor, in isoniazid toxic effect on rat primary hepatocytes.“These findings reveal the potential therapeutic value of combining DAS and DEX with INH in TB management for reducing the potential risk and incidences of hepatotoxicity.”
Investigating the CYP2E1 Potential Role in the Mechanisms Behind INH/LPS-Induced Hepatotoxicity
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