Possible Interaction: Isoleucine and Valine

“ Valine and isoleucine infusions resulted in twelve- and six-fold increases in the respective amino acid.”

“Indeed, we know now that while the BCAAs possess regulatory properties on protein metabolism, leucine is by far the most potent, while isoleucine and valine are inefficient.”

“The Caenorhabditis elegans ortholog of CHT1 has a valine residue at the corresponding position and a single replacement from valine to isoleucine caused a decrease in the choline uptake rate by 40%, suggesting that this hydrophobic residue is generally critical in the choline transport rate in CHT1.”

“Furthermore, the chlamydial growth inhibition induced by leucine, isoleucine , methionine, or phenylalanine was completely reversed by concomitant addition of valine.”

“On the other hand, Ile and Leu ratios decreased (Trp; tryptophan, Tyr; tyrosine, Phe; phenylalanine, Ile; isoleucine, Leu; leucine, Val; valine).”

“ Valine and isoleucine concentraions decreased (50-60%) as did to a lesser extent the concentrations of aromatic amino acids and methionine.”

“Abdominal fat yield was reduced with the combined supplementation of Val and Ile.”

“Feed efficiency improved when Val and Ile were simultaneously supplemented.”

“For instance valine and isoleucine frequently replace each other.”

“Supplementation of isoleucine and valine together resulted in better growth performance (P < 0.05) than supplementation of either amino acid alone.”

“Since valine and isoleucine competitively inhibited (Kis of 90 and 49 microM, respectively) leucine transport, it appeared that the peptostreptococcus used a common carrier for branched-chain amino acids.”