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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Isoleucine
supplement:
Threonine
Research Papers that Mention the Interaction
“Within the alpha1 transmembrane region, a single amino acid was identified that when mutated from threonine to isoleucine , increased furosemide sensitivity by 20-fold.”
Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.“During infusions of isoleucine and threonine , increases (P < .05) in isoleucine carbon uptake and threonine uptake, respectively, were observed.”
“Leu alone significantly decreased Lys, Ile and Thr serum concentrations; Ile significantly decreased Thr serum concentration; combined Leu and Ile significantly decreased Thr and significantly increased Val serum concentration.”
Supplemental leucine and isoleucine affect expression of cationic amino acid transporters and myosin, serum concentration of amino acids, and growth performance of pigs.“Increasing doses of Thr resulted in increased (P<0·05) concentrations of histidine and lysine, and decreased concentrations of isoleucine in whole-body protein.”
“Increasing doses of Thr resulted in increased (P < 0.05) concentrations of methionine, isoleucine , histidine and lysine in whole-body protein.”
“ Threonine was most effective in increasing the degree of parasitaemia but its effect was further enhanced when it was combined with dietary excess of certain other amino acids, notably valine, isoleucine and methionine.”
“ Abstract Isoleucine was found to be limiting for the growth of rats fed corn diets supplemented with lysine, tryptophan, valine, and threonine or 24% zein diets supplemented with most of the essential amino acids.”
“We have recently demonstrated that substitution of a specific Ile with Thr was sufficient to "short circuit" the complex cyclization reaction normally catalyzed by ent-kaurene synthases to instead produce ent-pimaradiene.”
A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase.“High concentrations of … allosteric inhibitor L-isoleucine ) decrease the rates of L-threonine and L-serine dehydratation and induce the appearance (at pH 6.5) or increase (at pH 7.9 and 9.5) of homotropic cooperative interactions between the active sites in the course of L-threonine dehydratation.”
“The enzyme inhibition by L-isoleucine increases with a decrease of L-threonine concentrations.”
“Reciprocal competitive inhibitions were found between threonine , aspartic acid, and isoleucine.”
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