Possible Interaction: Isoleucine and Serine

“We show that substitution of Ser 955, five residues N-terminal to the Tyr 960 autophosphorylation site (the −5 position), with Ile alters the target specificity of the IR such that it stably associates with Shc in insulin-stimulated cells.”

“ Isoleucine and serine together increased both insulin sensitivity and responsiveness to 60-70% of that seen with the full complement of amino acids.”

“Deficiency of medium isoleucine in the presence of serine rapidly decreased protein synthesis and insulin binding to intact cells.”

“At buried sites in β-strands, the content of Tyr, Trp, Gln and Ser correlates negatively with the content of Val, Ile and Leu (correlation coefficient = −0.93). "”

“Upon mutating isoleucines at two core positions to serines , we find that polymer stability is decreased while the degree of polymerization is about the same.”

“It has been reported that this L-serine inhibition may be prevented by the addition of L-isoleucine or L-threonine to the medium.”

“The reaction with l-serine was insensitive to inhibition by l-isoleucine and differed, in several respects from that with l-threonine.”

“ L-Serine inhibits the growth of E. coli cells in GM medium, and isoleucine releases this growth inhibition.”

“ L-Serine as well as L-valine inhibits the growth of Escherichia coli cells, and L-isoleucine releases this growth inhibition.”

“In the absence of isoleucine and valine, however, growth is severely inhibited by both L-serine and L-leucine.”