Possible Interaction: Isoleucine and Phenylalanine

“The overall catalytic efficiency (kcat/Km) for methionine and phenylalanine mutants was reduced approximately 3-fold and >6-fold for isoleucine and tyrosine mutants.”

“Moreover, the substitution of the phenylalanine residue with either alanine or isoleucine significantly reduced the amyloidogenic potential of the peptide fragment.”

“On the other hand, Ile and Leu ratios decreased (Trp; tryptophan, Tyr; tyrosine, Phe; phenylalanine , Ile; isoleucine, Leu; leucine, Val; valine).”

“Administration of certain large neutral amino‐acids (valine, isoleucine , leucine–VIL) appears to reduce phenylalanine concentrations in the cerebrospinal fluid of humans and in the brain of rats.”

“The VIL supplement brought about a significant reduction of the cerebrospinal fluid-serum ratio of phenylalanine from a mean value of 0.254 without VIL to 0.204 with VIL.”

“Feeding diets containing additional methionine and phenylalanine to protein-depleted rats caused a fall in concentration of the group of amino acids (leucine, isoleucine , valine and histidine) limiting growth.”

“Substitution of Phe by Ile in this series of ligands enhanced the AT2 receptor affinity of all compounds.”

“The Na+-independent component of isoleucine transport was inhibited by leucine, phenylalanine and 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) but neither by methylaminoisobutyric acid (MeAIB) nor lysine.”

“Uptake of Phe (0.2 mmol/L) was reduced by LNAA such as Val, Leu, and Ile (by 51%, 78%, and 81%, respectively), or by commercial preparations used in parenteral nutrition, eg, Travasol or Travasol plus extra branched-chain amino acids (BCAA) (Branchamin); Ser had little effect (8% reduction).”

“Hepatocytes prepared by collagenase perfusion from Antarctic nototheniid fish of genus Trematomus are active in uptake of […, 5, and 10 degrees C. The system is saturable with apparent Km about 1.0 mM. Isoleucine … phenylalanine were major competitors, valine was about one-… alanine, glycine and histidine had no effect.”