Possible Interaction: Isoleucine and Methionine

“The overall catalytic efficiency (kcat/Km) for methionine and phenylalanine mutants was reduced approximately 3-fold and >6-fold for isoleucine and tyrosine mutants.”

“When N-isoleucine is added to a fed supplement of methionine or methionine and cystine, the utilization of parenterally given hemoglobin N is even better than with the sulfur-containing amino acids alone.”

“Substitution of methionine for isoleucine at position 148 markedly decreased the Vmax of the enzyme for glycerolipids but had only a modest effect on the Km.”

“ Serum methionine fell significantly in both groups as did valine and isoleucine in the controls.”

“Via alanine, isoleucine , L-serine dehydratase/L-threonine deaminase and other proteins, AgNP-cit altered the metabolism of glycine, serine and threonine, cysteine and methionine , affecting oxidation and deamination, and ultimately leading to liver damage.”

“Phosphorylation of 4eBP1 increased in response to Ile and Met supplementation by 60 and 40%, respectively.”

“Replacement of the isoleucine of the wild-type rat IIA Na channel with a methionine (I874M) increases deltamethrin sensitivity 100-fold.”

“Because true microbial digestion of methionine, cystine, tyrosine, and isoleucine was reduced in the presence of high levels of methionine , we concluded that supplementation of dietary methionine could increase flows of these amino acids to the duodenum.”

“l -Ethionine and l -norleucine, as well as a number of neutral, nonpolar amino acids (leucine, isoleucine , valine, and alanine) also inhibit methionine uptake.”

“Phenylalanine and tyrosine inhibit one site; proline and the straight-chain amino acids, alanine, methionine and cysteine inhibit another; and glycine and the branched-chain valine, leucine, and isoleucine inhibit a 3rd.”