Possible Interaction: Isoleucine and Leucine

“ Isoleucine (p = 0.017) and valine (p = 0.006) concentration decreased more in the leucine supplemented group than in placebo in A samples.”

“The plasma concentrations of the keto acids of valine and isoleucine decreased by the leucine infusion while the concentrations of the keto acid of leucine and isoleucine decreased by glucose infusion.”

“Most previous studies have used experimental diets that included blood cells, which are particularly high in Leu and known to antagonize the use of Ile.”

“Computational analysis suggests that conformational changes in the hydrophobic pocket occur when leucine is substituted for isoleucine or valine and that this change leads to susceptibility to pleconaril.”

“Substitution of this leucine with an isoleucine , as found in the mouse zeta subunit, significantly reduces this interaction.”

“Plasma concentrations of essential amino acids, including threonine, methionine, isoleucine , valine, tyrosine, and phenylalanine were significantly decreased by leucine infusion.”

“Isoleucine and valine alone have little effect on human glutamate dehydrogenase, but isoleucine slightly inhibits the enzyme in the presence of leucine.”

“ Isoleucine (80-200 mumol/l) and valine (250-500 mumol/l) diminished transamination and oxidation of leucine up to 25%, glutamine (50-1000 mumol/l) up to 55%.”

“KICA and leucine greatly diminished KMVA, isoleucine , alpha-ketoisovaleric acid, and valine concentrations in blood.”

“During the infusion of leucine its concentration rose four- to six-folds, while the concentrations of several other amino acids declined continually, the effect being most pronounced for isoleucine (-55% of initial value), methionine (-55%), valine (-40%), tyrosine (-35%) and phenylalanine (-35%).”

“The uptake of isoleucine and methionine by the brain, seen in the basal state, was inhibited during leucine infusion.”