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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Isoleucine
drug:
Gabapentin
Research Papers that Mention the Interaction
“Although the neuroprotective mechanism of action of gabapentin is currently unknown, it is hypothesized here that gabapentin decreases the rate of formation of glutamate derived from the branched-chain amino acids (BCAAs) leucine, isoleucine , and valine.”
Potential Treatment of Amyotrophic Lateral Sclerosis with Gabapentin: A Hypothesis“4 Concentration‐dependent inhibition by unlabelled gabapentin of autoradiographic binding of L‐[3H]‐leucine and L‐[3H]‐isoleucine was observed, with non‐specific binding levels being reached at concentrations between 10 and 100 μm.”
Comparison of the autoradiographic binding distribution of [3H]‐gabapentin with excitatory amino acid receptor and amino acid uptake site distributions in rat brain
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