Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Isoflurophate and Trypsin



Research Papers that Mention the Interaction

The burst-stimulating effect of trypsin is enzymatic since it is completely prevented by DFP , a specific inhibitor of trypsin action.
The Journal of laboratory and clinical medicine  •  1980  |  View Paper
Thus pand y-chymotrypsins behave toward DFP in quite the same manner as the c11 … (5) (which may not be astonishing in view of their general similarity) ; however, DFP also … with trypsin to produce a crystallizable, inhibited trypsin whose equivalent weight … respect to phosphorus is about 20,000 (5).
The Journal of biological chemistry  •  1952  |  View Paper
Trypsin , alpha-chymotrypsin, and subtilisin were inactivated with diisopropyl fluorophosphate , and the distance of the phosphorus from Gd(III) in place of Ca(II) was determined from the lanthanide-induced relaxation on the 31P resonance.
Biochemistry  •  1989  |  View Paper
Such studies have shown that the reaction of trypsin with diisopropyl fluorophosphate (3) or diethyl p-nitrophenyl phosphate (DENP) (4) is accompanied by a loss in the proteolytic, esterase, and amidase activities of this enzyme.
The Journal of biological chemistry  •  1956  |  View Paper
It has been previously shown that the esterase and proteinase activities of trypsin and chymotrypsin (1, 2) were equally inhibited by diisopropyl fluorophosphate (DFP) (3).
The Journal of biological chemistry  •  1950  |  View Paper
Neither alveolar type II cells nor mesothelial cells showed increased labeling when trypsin inactivated by diisopropyl fluorophosphate was used.
Laboratory investigation; a journal of technical methods and pathology  •  1976  |  View Paper
The concentration of DFP employed was sufficient to have inhibited the esterolytic activity of proteases such as trypsin or chymotrypsin, if present.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1968  |  View Paper